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Codex DNA and RNAimmune Announce Collaboration to Optimize Development of Future mRNA Synthesis and Delivery Kits

November 22, 2021.

Agreement will allow researchers to streamline development of novel mRNA therapeutics and vaccines

SAN DIEGO, CA and GAITHERSBURG, MD — Nov. 22, 2021 — Codex DNA, Inc. (Nasdaq: DNAY), a pioneer in automated benchtop synthetic biology systems, and RNAimmune, a leading biotech company with expertise on messenger RNA (mRNA) design and delivery technologies, today announced initiation of work under a collaboration to optimize the development and validation of Codex DNA’s future mRNA synthesis kits.

Over the past two years, mRNA has emerged as a promising platform for the development of vaccines and therapeutics. However, robust and reliable production of mRNA remains challenging, resulting in significantly increased timelines during the critical phases of discovery and development that call for rapid iterations of construct designs for optimization. Codex DNA addresses these challenges by empowering researchers with an automated solution for their mRNA synthesis needs. Automated synthesis of mRNA from a digital sequence input reduces the build process by weeks and shrinks the iterative cycle time.

RNAimmune has expertise in mRNA technology and has proprietary design, delivery, and self-amplifying platforms focused on infectious diseases, autoimmune diseases, rare disorders, and immuno-oncology. As part of this collaboration, RNAimmune scientists will use their proprietary technology to rapidly evaluate and validate Codex DNA’s emerging solutions for automated synthesis and delivery of mRNA molecules with increasing complexity and functionality.

“Our partnership with Codex DNA can enhance their highly automated solutions for mRNA production,” said Dong Shen, MD, PhD, Founder and President of RNAimmune. “Together, we can incorporate our proprietary carrier molecules into Codex DNA’s mRNA synthesis kits to improve automated production toward truly transfection-ready mRNA with enhanced uptake and expression.”

“With our agreement with RNAimmune, our customers may be able to develop life-saving mRNA-based treatments and vaccines much faster and more easily than before,” said Todd R. Nelson, PhD, CEO of Codex DNA. “We look forward to working with the RNAimmune team to validate our highly functional mRNA synthesis kits and potentially integrate RNAimmune’s proprietary mRNA delivery solutions into our automated workflows.”

About RNAimmune, Inc.

RNAimmune is a biopharmaceutical company specializing in discovery and development of messenger RNA (mRNA) therapeutics and vaccines. The Company leverages mRNA as a data carrier to instruct the human body to produce its own proteins capable of fighting a wide range of diseases. RNAimmune is a spin-off venture from Sirnaomics, Inc. and has received a global exclusive right to the proprietary Polypeptide Lipid Nanoparticle (PLNP) technology for mRNA delivery from Sirnaomics. The Company has also developed a proprietary A.I. algorithm (ALEPVA) for antigen prediction and vaccine design. By integrating multiple established platform technologies, RNAimmune is aiming to develop a comprehensive mRNA drug discovery and development platform, from which the Company will enrich its therapeutic and vaccine product pipeline addressing tremendous unmet needs in treatments of viral infections, cancer and rare diseases. To learn more about RNAimmune, please visit the company

website: www.rnaimmune.com.

About Codex DNA

Codex DNA is empowering scientists with the ability to create novel, synthetic biology-enabled solutions for many of humanity’s greatest challenges. As inventors of the industry-standard Gibson Assembly® method and the first commercial automated benchtop DNA and mRNA synthesis system, Codex DNA is enabling rapid, accurate, and reproducible writing of DNA and mRNA for numerous downstream markets. The company’s award-winning BioXp™ system consolidates, automates, and optimizes the entire synthesis, cloning, and amplification workflow. As a result, it delivers virtually error-free synthesis of DNA/RNA at scale within days and hours instead of weeks or months. Scientists around the world are using the technology in their own laboratories to accelerate the design-build-test paradigm for novel, high-value products for precision medicine, biologics drug discovery, vaccine and therapeutic development, genome editing, and cell and gene therapy. Codex DNA is a public company based in San Diego. For more information, visit codexdna.com.

Forward-Looking Statements

This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Such forward-looking statements are based on Codex DNA’s beliefs and assumptions and on information currently available to it on the date of this press release. Forward-looking statements may involve known and unknown risks, uncertainties and other factors that may cause Codex DNA’s actual results, performance or achievements to be materially different from those expressed or implied by the forward-looking statements. These statements include but are not limited to statements regarding Codex DNA’s ability to successfully integrate the RNA immune’s capabilities with mRNA design and delivery into its products. These and other risks are described more fully in Codex DNA’s filings with the Securities and Exchange Commission (“SEC”) and other documents that Codex DNA subsequently files with the SEC from time to time. Except to the extent required by law, Codex DNA undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

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Contacts:

RNAimmune Inc.

Stanley He, Chief Business Officer

(240) 810-2639 stanley@rnaimmune.com

Codex DNA

Richard Lepke, Director of Investor Relations

(619) 840-5392 RichardL@codexdna.com

About Sirnaomics, Inc.

Sirnaomics, Inc., a leading privately held biopharmaceutical company for discovery and development of RNAi therapeutics, is a Delaware corporation headquartered in Gaithersburg, Maryland, USA, with subsidiaries in Suzhou and Guangzhou, China. The Company’s mission is to develop novel therapeutics to alleviate human suffering and advance patient care in areas of high unmet medical need. The guiding principles of the company are: Innovation, Global Vision with a Patient Centered focus. Members of the senior management team have a great deal of combined experience in the biopharmaceutical industry, financial, clinical and business management in both the USA and China. The company is supported by funding from institutional investors and corporate partnerships. Sirnaomics has developed a strong portfolio of intellectual property with an enriched product pipeline. The therapeutic areas of focus include oncology and anti-fibrotic therapeutics. Learn more at www.sirnaomics.com.