Our core product candidate, STP705, is a dual TGF-ß1/COX-2 inhibitor. TGF-ß1 and COX-2 are well-validated gatekeeper targets for oncology and fibrosis disease drug development. STP705 leverages our locally administered PNP formulation for direct administration to diseased tissue. We are developing STP705 for NMSC including isSCC, dermal fibrosis and solid liver tumors.

STP705 has received U.S. orphan drug designation for the treatment of certain hepatocellular carcinomas and liver fibrosis, including: primary sclerosing cholangitis (PSC), cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC).

STP707, our second core product, is in early-stage development for the treatment of solid tumors, liver cancer, squamous cell carcinoma, and non-small cell lung cancer (NSCLC). The annual incidence of NSCLC in 2020 was larger in China (approximately 757,000 new cases) than in the U.S. (approximately 176,000 new cases), and is only expected to grow. STP707 is an intravenously administered TGF-ß1 and COX-2 inhibitor that leverages an RNAi-based response using the company’s proprietary PNP delivery platform. It is being studied as a monotherapy and in combination with anti-PD(L)-1 therapy in early-stage clinical trials taking place in the U.S. and China.

STP355 is an siRNA-based treatment for multiple cancer types, including breast cancer, melanoma, and colorectal cancer. It targets TGF-ß1 and VEGFR2 proteins, and is formulated with our PNP delivery platform.

STP369 is an siRNA treatment for head and neck cancer, and bladder cancer which targets BCL-xL and MCL-1 proteins and is formulated with our PNP delivery platform. We are also exploring the use of STP369 in combination with platinum-based chemotherapy cisplatin to evaluate the potential for STP369 to improve the efficacy of cisplatin or replace its use.

STP779 is an siRNA-based treatment for liver cancer, lung cancer and pancreatic cancer. It target TGF-ß1 and SULF-2, and is formulated with our PNP delivery platform.