Sirnaomics Carrers Careers

Pexels Chokniti Khongchum 3938022
Organic Chemist
Full Time

Sirnaomics, Inc. is a leading clinical stage biopharmaceutical company in the discovery and development of RNAi therapeutics for treatment of cancer and fibrotic diseases.  We are seeking candidates to fill the newly created position of Organic Chemist in our headquarters in Gaithersburg, MD.

The successful candidate will provide synthetic related support for RNAi drug R&D projects by designing and conducting the synthesis, purification and characterization of oligonucleotide small molecule conjugates; contribute to the development of novel siRNA drug delivery design, and; participate in other early project developments.

To be considered for this position, the well qualified candidate will have an advanced degree (Ph.D./MS or equivalent) in RNA and/or DNA Chemistry, Organic Chemistry, Biochemistry, Nanotechnology or equivalent scientific discipline and two or more years of relevant experience in conjugation chemistry applied to biological systems.   The well qualified candidate will also have:

  • Demonstrated knowledge of Oligonucleotide conjugation;
  • Experience in synthesis of small organic molecules (experience in galactose derivatives and peptide chemistry will be a strong plus).
  • In-depth knowledge in organic and nucleic acid chemistry.
  • Proven scientific and technical ability to design and execute synthetic route, product purification, optimization of chemistry, and analysis and present data.
  • Experience in analytical methods such as NMR, HPLC, LCMS, UV-vis and IR.
  • Broad experience in purification techniques such as revers phase, GPC, IEX chromatography, preparative HPLC.

Sirnaomics is an Equal Opportunity Employer, and offers a fast paced/dynamic environment, growth opportunity, competitive compensation and a full benefits program.

For consideration, please submit your resume to and reference 21-038. Only those candidates selected for an interview will be contacted.