Sirnaomics, Inc. is a leading clinical-stage biopharmaceutical company in the discovery and development of RNAi therapeutics for treatment of cancer and fibrotic diseases. We are seeking Scientist in Chemistry candidates with a solid background and experience in Organic Synthesis, RNA drug delivery, and oligonucleotide conjugation chemistry. This individual will contribute to Sirnaomics’s growth by providing synthetic support for RNAi drug R&D projects in a dynamic lab setting, where both discovery and process chemistry projects are on-going.
The successful candidate will design, and conduct the synthesis, purification, and characterization of oligonucleotide small molecule conjugates, or of interest, contribute to the development of novel siRNA drug delivery design, maintain excellent laboratory records, and write reports and research summaries as required, interact closely with other scientists to develop comprehensive solutions, good organization skills with an ability to manage priorities and multi-task, and participate in intellectual property creation.
To be considered for this position, the well-qualified candidate will have an advanced degree to include either a Ph.D. in RNA and/or DNA Chemistry, Organic Chemistry, Biochemistry, Nanotechnology, or equivalent scientific discipline. The successful candidate will have experience in conjugation chemistry applied to biological systems. Knowledge of Oligonucleotide conjugation is required, synthesis experience in small organic molecules is a must, experience in galactose derivatives and peptide chemistry will be a strong plus, in-depth knowledge in organic and nucleic acid chemistry, proven scientific and technical ability to design and execute synthetic route, product purification, optimization of chemistry, and analysis and present data, experience in analytical methods such as NMR, HPLC, LCMS, UV-vis and IR, broad experience in purification techniques such as reverse phase, GPC, IEX chromatography, preparative HPLC. The preferred candidate is highly motivated and a self-driven individual with the ability to work independently, and multi-task under an aggressive timeline to support team and corporate objectives.
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